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ABOUT KALIVIR

[/fusion_title][fusion_separator style_type=”default” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”” id=”” sep_color=”#d8d8d8″ top_margin=”30px” bottom_margin=”60px” border_size=”1px” icon=”” icon_size=”” icon_circle=”” icon_circle_color=”” width=”40%” alignment=”center” /][/fusion_builder_column][fusion_builder_column type=”1_1″ layout=”1_1″ background_position=”left top” background_color=”” border_color=”” border_style=”solid” spacing=”yes” background_image=”” background_repeat=”no-repeat” padding_top=”” padding_right=”” padding_bottom=”” padding_left=”” margin_top=”0px” margin_bottom=”0px” class=”” id=”” animation_type=”” animation_speed=”0.3″ animation_direction=”left” hide_on_mobile=”no” center_content=”no” min_height=”none” last=”true” hover_type=”none” link=”” border_position=”all” align_self=”flex-start” border_sizes_top=”” border_sizes_bottom=”” border_sizes_left=”” border_sizes_right=”” first=”true” type=”1_1″][fusion_title title_type=”text” rotation_effect=”bounceIn” display_time=”1200″ highlight_effect=”circle” loop_animation=”off” highlight_width=”9″ highlight_top_margin=”0″ before_text=”” rotation_text=”” highlight_text=”” after_text=”” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”” id=”” content_align=”left” size=”3″ font_size=”” animated_font_size=”” fusion_font_family_title_font=”” fusion_font_subset_title_font=”” fusion_font_variant_title_font=”” line_height=”” letter_spacing=”” margin_top=”0px” margin_bottom=”20px” margin_top_mobile=”” margin_bottom_mobile=”” text_color=”” animated_text_color=”” highlight_color=”” style_type=”none” sep_color=”” animation_type=”” animation_direction=”left” animation_speed=”0.3″ animation_offset=”” margin_top_small=”” margin_bottom_small=””]

FOUNDATION

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KaliVir Immunotherapeutics was founded in 2019 to pioneer a unique and novel approach to cancer treatment that engages a virus’ natural ability to replicate in and kill cancer cells. This modality is known as oncolytic viral immunotherapy. KaliVir’s cutting-edge, next generation oncolytic viral immunotherapy programs combine technologies developed in-house and licensed from The University of Pittsburgh’s world-class oncolytic virus and immunotherapy research program.

SOLUTION

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KaliVir is engineering vaccinia virus-based oncolytic viral immunotherapies that can be delivered intravenously to cancer patients, eliminating the need for complicated surgical procedures required for direct intra-tumoral administration.

MULTIPLE MECHANISMS TO ATTACK CANCER

KaliVir’s novel oncolytic viruses attack cancer in multiple ways to maximize replication of the viruses, spread of the viruses, expression of therapeutic transgene (therapeutic payload) matched to certain tumor immunophenotypes and/or unique biomarkers. KaliVir’s oncolytic product candidates are designed to be safe, potent and systemically deliverable to treat cancer patients across multiple tumor types. KaliVir is now advancing multiple therapeutic candidates towards the clinic.

[/fusion_text][fusion_separator style_type=”none” top_margin=”40px” bottom_margin=”40px” sep_color=”#e0e0e0″ border_size=”1px” width=”60%” alignment=”center” /][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container][fusion_builder_container hundred_percent=”yes” overflow=”visible” type=”legacy”][fusion_builder_row][fusion_builder_column type=”1_1″ layout=”1_1″ background_position=”left top” background_color=”” border_color=”” border_style=”solid” spacing=”yes” background_image=”” background_repeat=”no-repeat” padding_top=”” padding_right=”” padding_bottom=”” padding_left=”” margin_top=”0px” margin_bottom=”0px” class=”” id=”” animation_type=”” animation_speed=”0.3″ animation_direction=”left” hide_on_mobile=”no” center_content=”no” min_height=”none” last=”true” hover_type=”none” link=”” border_position=”all” align_self=”flex-start” border_sizes_top=”” border_sizes_bottom=”” border_sizes_left=”” border_sizes_right=”” first=”true” type=”1_1″][fusion_menu_anchor name=”approach” class=”” /][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container][fusion_builder_container background_color=”#619e85″ background_image=”http://kalivir.macb.io/wp-content/uploads/2016/08/tech-features-bg.png” background_parallax=”none” enable_mobile=”no” parallax_speed=”0.3″ background_repeat=”repeat-x” background_position=”center bottom” video_aspect_ratio=”16:9″ video_mute=”yes” video_loop=”yes” fade=”no” border_style=”solid” padding_top=”110px” padding_bottom=”110px” hundred_percent=”no” equal_height_columns=”no” hide_on_mobile=”no” type=”legacy” border_sizes_top=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_sizes_right=”0px”][fusion_builder_row][fusion_builder_column type=”1_1″ layout=”1_1″ background_position=”left top” background_color=”” border_color=”” border_style=”solid” spacing=”yes” background_image=”” background_repeat=”no-repeat” padding_top=”” padding_right=”” padding_bottom=”” padding_left=”” margin_top=”0px” margin_bottom=”0px” class=”” id=”” animation_type=”” animation_speed=”0.3″ animation_direction=”left” hide_on_mobile=”no” center_content=”no” min_height=”none” last=”true” hover_type=”none” link=”” border_position=”all” align_self=”flex-start” border_sizes_top=”” border_sizes_bottom=”” border_sizes_left=”” border_sizes_right=”” first=”true” type=”1_1″][fusion_title title_type=”text” rotation_effect=”bounceIn” display_time=”1200″ highlight_effect=”circle” loop_animation=”off” highlight_width=”9″ highlight_top_margin=”0″ before_text=”” rotation_text=”” highlight_text=”” after_text=”” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”” id=”” content_align=”center” size=”1″ font_size=”” animated_font_size=”” fusion_font_family_title_font=”” fusion_font_subset_title_font=”” fusion_font_variant_title_font=”” line_height=”” letter_spacing=”” margin_top=”0px” margin_bottom=”20px” margin_top_mobile=”” margin_bottom_mobile=”” text_color=”” animated_text_color=”” highlight_color=”” style_type=”none” sep_color=”” animation_type=”” animation_direction=”left” animation_speed=”0.3″ animation_offset=”” margin_top_small=”” margin_bottom_small=””]OUR APPROACH[/fusion_title][fusion_separator style_type=”single” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sep_color=”#386955″ top_margin=”30px” bottom_margin=”60px” border_size=”1px” width=”40%” alignment=”center” /][/fusion_builder_column][fusion_builder_column type=”1_1″ layout=”1_1″ background_position=”left top” background_color=”” border_color=”” border_style=”solid” spacing=”yes” background_image=”” background_repeat=”no-repeat” padding_top=”” padding_right=”” padding_bottom=”” padding_left=”” margin_top=”0px” margin_bottom=”0px” class=”” id=”” animation_type=”” animation_speed=”0.3″ animation_direction=”left” hide_on_mobile=”no” center_content=”no” min_height=”none” last=”true” hover_type=”none” link=”” border_position=”all” align_self=”flex-start” border_sizes_top=”” border_sizes_bottom=”” border_sizes_left=”” border_sizes_right=”” first=”true” type=”1_1″][fusion_title title_type=”text” rotation_effect=”bounceIn” display_time=”1200″ highlight_effect=”circle” loop_animation=”off” highlight_width=”9″ highlight_top_margin=”0″ before_text=”” rotation_text=”” highlight_text=”” after_text=”” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”” id=”” content_align=”left” size=”2″ font_size=”” animated_font_size=”” fusion_font_family_title_font=”” fusion_font_subset_title_font=”” fusion_font_variant_title_font=”” line_height=”” letter_spacing=”” margin_top=”0px” margin_bottom=”20px” margin_top_mobile=”” margin_bottom_mobile=”” text_color=”” animated_text_color=”” highlight_color=”” style_type=”none” sep_color=”” animation_type=”” animation_direction=”left” animation_speed=”0.3″ animation_offset=”” margin_top_small=”” margin_bottom_small=””]

HOW ONCOLYTIC VIRAL IMMUNOTHERAPY WORKS

Oncolytic viral immunotherapy utilizes engineered viruses that can preferentially infect and kill cancer cells thereby generating de novo or boosting pre-existing anti-tumor immunity to combat cancer. Most oncolytic viruses are genetically modified to enhance tumor tropism or tumor targeting abilities, so that the virus’ virulence against non-tumor cells are significantly reduced. This allows the virus to replicate preferentially in tumor cells and leave normal cells unharmed.

In addition to direct cell killing abilities, oncolytic viruses can also stimulate a pro-inflammatory environment within the host tumor as well as enhancing antigen release and recognition. This immune activation can counteract the immune evasiveness of tumors. In essence, the virus stimulates a systemic immune response that can combat cancer.

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Traditional and early-generation oncolytic immunotherapies are limited by the patient’s anti-viral immune response. This has led to several limitations that include: limited systemic delivery; ineffective payload; and failure to effectively immuno-modulate the tumor microenvironment.

KaliVir’s unique approach to developing next-generation oncolytic viral immunotherapies is based on:

Using vaccinia virus as an ideal systemic delivery platform template;
Enhancing the vaccinia backbone with a proprietary combination of genetic modification and insertions to achieve optimal oncolytic potential, including systemic delivery and spread within the tumor;
Augmenting the vaccinia backbone with the ability to overcome immunosuppression and to increase effector T-cell populations that can better attack tumors;
Engaging vaccinia’s large payload expressing capabilities to add therapeutic transgenes that maximize multi-mechanistic immunotherapeutic effects and are synergistic with other immunotherapies.

THE VACCINIA ENHANCED TEMPLATE (VET™) PLATFORM

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KaliVir has developed a potent, novel oncolytic platform called the Vaccinia Enhanced Template (VET™). KaliVir’s VET™ Platform includes multiple proprietary genetic modifications that can be combined to generate a unique oncolytic virus that has been optimized for systemic therapeutic transgene delivery and expression. Preclinical studies with VET™ Platform have demonstrated exponential increase in systemic delivery and in oncolytic activity. Furthermore, studies demonstrated enhanced immunotherapeutic effects compared to earlier generations of oncolytic vaccinia virus.

VET™ platform is designed to:

Enhance systemic (IV) delivery capabilities
Enhance tumor-targeted replication
Enhance viral spread to metastatic tumors
Enhance viral spread within tumor microenvironment.

The VET™ Platform is designed for systemic intravenous delivery and serves as a best-in-class and versatile viral backbone on which tailored transgene programs are being developed. VET™ Platform is also highly synergistic with other immunotherapeutic modalities such as immune checkpoint blockade, and is well-positioned to be quickly moved forward in clinical development.

[/fusion_text][fusion_imageframe image_id=”599|full” max_width=”” style_type=”dropshadow” blur=”” stylecolor=”rgba(0,0,0,0.81)” hover_type=”none” bordersize=”” bordercolor=”” borderradius=”” align=”center” lightbox=”yes” gallery_id=”” lightbox_image=”http://kalivir.macb.io/wp-content/uploads/2020/05/VET_Kalivir.width-800-1.png” lightbox_image_id=”599|full” alt=”THE VACCINIA ENHANCED TEMPLATE (VET™) PLATFORM” link=”” linktarget=”_self” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”” id=”” animation_type=”slide” animation_direction=”left” animation_speed=”1.0″ animation_offset=”top-into-view” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″]http://kalivir.macb.io/wp-content/uploads/2020/05/VET_Kalivir.width-800-1.png[/fusion_imageframe][fusion_title title_type=”text” rotation_effect=”bounceIn” display_time=”1200″ highlight_effect=”circle” loop_animation=”off” highlight_width=”9″ highlight_top_margin=”0″ before_text=”” rotation_text=”” highlight_text=”” after_text=”” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” class=”” id=”” content_align_medium=”” content_align_small=”” content_align=”left” size=”6″ font_size=”18px” animated_font_size=”” fusion_font_family_title_font=”” fusion_font_variant_title_font=”” line_height=”” letter_spacing=”” margin_top_medium=”” margin_bottom_medium=”” margin_top_small=”” margin_bottom_small=”” margin_top=”0px” margin_bottom=”20px” margin_top_mobile=”” margin_bottom_mobile=”” text_color=”” animated_text_color=”” highlight_color=”” style_type=”none” sep_color=”” animation_type=”” animation_direction=”left” animation_speed=”0.3″ animation_offset=””]

Download Kalivir VACCINIA ENHANCED TEMPLATE (VET™) Graphic

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TOMORROW’S TECHNOLOGY,
TODAY’S CURE.

Unique capacity to deliver gene therapies directly to the tumor.

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Delivery mechanism to zip code different therapies to different tumors.

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Natural and engineered ability to target the immune response against the tumor.

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Overcomes the tumor’s immunosuppressive capabilities on multiple levels.

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Repeated treatment possible even after initial immune response is raised.

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KALIVIR’S DEVELOPMENT PIPELINE

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LEAD CLINICAL CANDIDATE

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Download VET2-L2 Graphic

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type=”1_1″][fusion_title title_type=”text” rotation_effect=”bounceIn” display_time=”1200″ highlight_effect=”circle” loop_animation=”off” highlight_width=”9″ highlight_top_margin=”0″ before_text=”” rotation_text=”” highlight_text=”” after_text=”” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”” id=”” content_align=”center” size=”1″ font_size=”” animated_font_size=”” fusion_font_family_title_font=”” fusion_font_subset_title_font=”” fusion_font_variant_title_font=”” line_height=”” letter_spacing=”” margin_top=”0px” margin_bottom=”20px” margin_top_mobile=”” margin_bottom_mobile=”” text_color=”” animated_text_color=”” highlight_color=”” style_type=”none” sep_color=”” animation_type=”” animation_direction=”left” animation_speed=”0.3″ animation_offset=”” margin_top_small=”” margin_bottom_small=””]OUR TEAM[/fusion_title][fusion_title title_type=”text” rotation_effect=”bounceIn” display_time=”1200″ highlight_effect=”circle” loop_animation=”off” highlight_width=”9″ highlight_top_margin=”0″ before_text=”” rotation_text=”” highlight_text=”” after_text=”” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”” id=”” content_align=”center” size=”3″ font_size=”” animated_font_size=”” fusion_font_family_title_font=”” fusion_font_subset_title_font=”” fusion_font_variant_title_font=”” line_height=”” letter_spacing=”” margin_top=”0px” margin_bottom=”20px” margin_top_mobile=”” margin_bottom_mobile=”” text_color=”” animated_text_color=”” highlight_color=”” style_type=”none” sep_color=”” animation_type=”” animation_direction=”left” animation_speed=”0.3″ animation_offset=”” margin_top_small=”” margin_bottom_small=””]

Our people are pioneers in VIRAL IMMUNOTHERAPY

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LEADERSHIP

HELENA CHAYE, Ph.D., J.D.
Chief Executive Officer

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STEPHEN H. THORNE, Ph.D.
Chief Scientific Officer

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JAMES M. BURKE, M.D.
Chief Medical Officer

GEORG ROTH, Ph.D.
CMC Advisor

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URSULA FRITSCH, PharmD
Regulatory and Quality Advisor

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GREGG BELOFF, J.D., M.B.A
Finance Advisor

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GREG M. DELGOFFE, Ph.D.
University of Pittsburgh

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JOY A. CAVAGNARO, Ph.D.
Access BIO

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LISA BUTTERFIELD, Ph.D.
University of California San Francisco

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TULLIO BRUNO, Ph.D.
University of Pittsburgh

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JORGE NIEVA, M.D.
USC

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JONATHAN E. ROSENBERG, M.D.
Memorial Sloan Kettering

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DMITRIY ZAMARIN, M.D., Ph.D.
Memorial Sloan Kettering

MITESH BORAD, M.D.
Mayo Clinic

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JOHN NEMUNAITIS, M.D.
University of Toledo

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padding_right_small=”” padding_bottom_small=”” padding_left_small=”” padding_top=”0px” padding_right=”0px” padding_bottom=”0px” padding_left=”0px” hover_type=”none” border_sizes_top=”0″ border_sizes_right=”0″ border_sizes_bottom=”0″ border_sizes_left=”0″ border_color=”” border_style=”solid” border_radius_top_left=”” border_radius_top_right=”” border_radius_bottom_right=”” border_radius_bottom_left=”” box_shadow=”no” box_shadow_vertical=”” box_shadow_horizontal=”” box_shadow_blur=”0″ box_shadow_spread=”0″ box_shadow_color=”” box_shadow_style=”” background_type=”single” gradient_start_color=”” gradient_end_color=”” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_color=”” background_image=”” background_position=”left top” background_repeat=”no-repeat” background_blend_mode=”none” animation_type=”” animation_direction=”left” animation_speed=”1.0″ animation_offset=”top-into-view” filter_type=”regular” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ last=”false” border_position=”all” first=”true” type=”1_4″][fusion_title title_type=”text” rotation_effect=”bounceIn” display_time=”1200″ highlight_effect=”circle” loop_animation=”off” highlight_width=”9″ highlight_top_margin=”0″ before_text=”” rotation_text=”” highlight_text=”” after_text=”” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”” id=”” content_align=”left” size=”3″ font_size=”” animated_font_size=”” fusion_font_family_title_font=”” fusion_font_subset_title_font=”” fusion_font_variant_title_font=”” line_height=”” letter_spacing=”” margin_top=”” margin_bottom=”0px” margin_top_mobile=”” margin_bottom_mobile=”” text_color=”” animated_text_color=”” highlight_color=”” style_type=”none” sep_color=”” animation_type=”” animation_direction=”left” animation_speed=”0.3″ animation_offset=”” margin_top_small=”” margin_bottom_small=””]

HELENA CHAYE, Ph.D., J.D.
Director

[/fusion_title][fusion_separator style_type=”none” top_margin=”30px” bottom_margin=”30px” sep_color=”#969696″ border_size=”1px” width=”60%” alignment=”left” /][/fusion_builder_column][fusion_builder_column type=”1_4″ layout=”1_4″ align_self=”auto” content_layout=”column” align_content=”flex-start” content_wrap=”wrap” spacing=”no” center_content=”no” link=”” target=”_self” min_height=”” hide_on_mobile=”no” sticky_display=”normal,sticky” class=”” id=”” background_image_id=”” type_medium=”” type_small=”” order_medium=”0″ order_small=”0″ spacing_left_medium=”” spacing_right_medium=”” spacing_left_small=”” spacing_right_small=”” spacing_left=”0px” spacing_right=”0px” margin_top_medium=”” margin_bottom_medium=”” margin_top_small=”” margin_bottom_small=”” margin_top=”” margin_bottom=”0px” padding_top_medium=”” padding_right_medium=”” padding_bottom_medium=”” padding_left_medium=”” padding_top_small=”” padding_right_small=”” padding_bottom_small=”” padding_left_small=”” padding_top=”0px” padding_right=”0px” padding_bottom=”0px” padding_left=”0px” hover_type=”none” border_sizes_top=”0″ border_sizes_right=”0″ border_sizes_bottom=”0″ border_sizes_left=”0″ border_color=”” border_style=”solid” border_radius_top_left=”” border_radius_top_right=”” border_radius_bottom_right=”” border_radius_bottom_left=”” box_shadow=”no” box_shadow_vertical=”” box_shadow_horizontal=”” box_shadow_blur=”0″ box_shadow_spread=”0″ box_shadow_color=”” box_shadow_style=”” background_type=”single” gradient_start_color=”” gradient_end_color=”” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_color=”” background_image=”” background_position=”left top” background_repeat=”no-repeat” background_blend_mode=”none” animation_type=”” animation_direction=”left” animation_speed=”1.0″ animation_offset=”top-into-view” filter_type=”regular” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ last=”false” border_position=”all” first=”false” type=”1_4″][fusion_title title_type=”text” rotation_effect=”bounceIn” display_time=”1200″ highlight_effect=”circle” loop_animation=”off” highlight_width=”9″ highlight_top_margin=”0″ before_text=”” rotation_text=”” highlight_text=”” after_text=”” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”” id=”” content_align=”left” size=”3″ font_size=”” animated_font_size=”” fusion_font_family_title_font=”” fusion_font_subset_title_font=”” fusion_font_variant_title_font=”” line_height=”” letter_spacing=”” margin_top=”” margin_bottom=”0px” margin_top_mobile=”” margin_bottom_mobile=”” text_color=”” animated_text_color=”” highlight_color=”” style_type=”none” sep_color=”” animation_type=”” animation_direction=”left” animation_speed=”0.3″ animation_offset=”” margin_top_small=”” margin_bottom_small=””]

STEPHEN H. THORNE, Ph.D.
Director

[/fusion_title][fusion_separator style_type=”none” top_margin=”30px” bottom_margin=”30px” sep_color=”#969696″ border_size=”1px” width=”60%” alignment=”left” /][/fusion_builder_column][fusion_builder_column type=”1_4″ layout=”1_4″ align_self=”auto” content_layout=”column” align_content=”flex-start” content_wrap=”wrap” spacing=”no” center_content=”no” link=”” target=”_self” min_height=”” hide_on_mobile=”no” sticky_display=”normal,sticky” class=”” id=”” background_image_id=”” type_medium=”” type_small=”” order_medium=”0″ order_small=”0″ spacing_left_medium=”” spacing_right_medium=”” spacing_left_small=”” spacing_right_small=”” spacing_left=”0px” spacing_right=”0px” margin_top_medium=”” margin_bottom_medium=”” margin_top_small=”” margin_bottom_small=”” margin_top=”” margin_bottom=”0px” padding_top_medium=”” padding_right_medium=”” padding_bottom_medium=”” padding_left_medium=”” padding_top_small=”” padding_right_small=”” padding_bottom_small=”” padding_left_small=”” padding_top=”0px” padding_right=”0px” padding_bottom=”0px” padding_left=”0px” hover_type=”none” border_sizes_top=”0″ border_sizes_right=”0″ border_sizes_bottom=”0″ border_sizes_left=”0″ border_color=”” border_style=”solid” border_radius_top_left=”” border_radius_top_right=”” border_radius_bottom_right=”” border_radius_bottom_left=”” box_shadow=”no” box_shadow_vertical=”” box_shadow_horizontal=”” box_shadow_blur=”0″ box_shadow_spread=”0″ box_shadow_color=”” box_shadow_style=”” background_type=”single” gradient_start_color=”” gradient_end_color=”” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_color=”” background_image=”” background_position=”left top” background_repeat=”no-repeat” background_blend_mode=”none” animation_type=”” animation_direction=”left” animation_speed=”1.0″ animation_offset=”top-into-view” filter_type=”regular” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ last=”false” border_position=”all” first=”false” type=”1_4″][fusion_title title_type=”text” rotation_effect=”bounceIn” display_time=”1200″ highlight_effect=”circle” loop_animation=”off” highlight_width=”9″ highlight_top_margin=”0″ before_text=”” rotation_text=”” highlight_text=”” after_text=”” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”” id=”” content_align=”left” size=”3″ font_size=”” animated_font_size=”” fusion_font_family_title_font=”” fusion_font_subset_title_font=”” fusion_font_variant_title_font=”” line_height=”” letter_spacing=”” margin_top=”” margin_bottom=”0px” margin_top_mobile=”” margin_bottom_mobile=”” text_color=”” animated_text_color=”” highlight_color=”” style_type=”none” sep_color=”” animation_type=”” animation_direction=”left” animation_speed=”0.3″ animation_offset=”” margin_top_small=”” margin_bottom_small=””]

RICHARD JONES, M.B.A.
Director

[/fusion_title][fusion_separator style_type=”none” top_margin=”30px” bottom_margin=”30px” sep_color=”#969696″ border_size=”1px” width=”60%” alignment=”left” /][/fusion_builder_column][fusion_builder_column type=”1_4″ layout=”1_4″ align_self=”auto” content_layout=”column” align_content=”flex-start” content_wrap=”wrap” spacing=”no” center_content=”no” link=”” target=”_self” min_height=”” hide_on_mobile=”no” sticky_display=”normal,sticky” class=”” id=”” background_image_id=”” type_medium=”” type_small=”” order_medium=”0″ order_small=”0″ spacing_left_medium=”” spacing_right_medium=”” spacing_left_small=”” spacing_right_small=”” spacing_left=”0px” spacing_right=”” margin_top_medium=”” margin_bottom_medium=”” margin_top_small=”” margin_bottom_small=”” margin_top=”” margin_bottom=”0px” padding_top_medium=”” padding_right_medium=”” padding_bottom_medium=”” padding_left_medium=”” padding_top_small=”” padding_right_small=”” padding_bottom_small=”” padding_left_small=”” padding_top=”0px” padding_right=”0px” padding_bottom=”0px” padding_left=”0px” hover_type=”none” border_sizes_top=”0″ border_sizes_right=”0″ border_sizes_bottom=”0″ border_sizes_left=”0″ border_color=”” border_style=”solid” border_radius_top_left=”” border_radius_top_right=”” border_radius_bottom_right=”” border_radius_bottom_left=”” box_shadow=”no” box_shadow_vertical=”” box_shadow_horizontal=”” box_shadow_blur=”0″ box_shadow_spread=”0″ box_shadow_color=”” box_shadow_style=”” background_type=”single” gradient_start_color=”” gradient_end_color=”” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_color=”” background_image=”” background_position=”left top” background_repeat=”no-repeat” background_blend_mode=”none” animation_type=”” animation_direction=”left” animation_speed=”1.0″ animation_offset=”top-into-view” filter_type=”regular” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ last=”true” border_position=”all” first=”false” type=”1_4″][fusion_title title_type=”text” rotation_effect=”bounceIn” display_time=”1200″ highlight_effect=”circle” loop_animation=”off” highlight_width=”9″ highlight_top_margin=”0″ before_text=”” rotation_text=”” highlight_text=”” after_text=”” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”” id=”” content_align=”left” size=”3″ font_size=”” animated_font_size=”” fusion_font_family_title_font=”” fusion_font_subset_title_font=”” fusion_font_variant_title_font=”” line_height=”” letter_spacing=”” margin_top=”” margin_bottom=”0px” margin_top_mobile=”” margin_bottom_mobile=”” text_color=”” animated_text_color=”” highlight_color=”” style_type=”none” sep_color=”” animation_type=”” animation_direction=”left” animation_speed=”0.3″ animation_offset=”” margin_top_small=”” margin_bottom_small=””]

TOM LEONARD
Director

JON WIGGINTON, M.D.
Director

[/fusion_title][fusion_separator style_type=”none” top_margin=”30px” bottom_margin=”30px” sep_color=”#969696″ border_size=”1px” width=”60%” alignment=”left” /][/fusion_builder_column][fusion_builder_column type=”1_3″ layout=”1_3″ align_self=”auto” content_layout=”column” align_content=”flex-start” content_wrap=”wrap” spacing=”no” center_content=”no” link=”” target=”_self” min_height=”” hide_on_mobile=”no” sticky_display=”normal,sticky” class=”” id=”” background_image_id=”” type_medium=”” type_small=”” order_medium=”0″ order_small=”0″ spacing_left_medium=”” spacing_right_medium=”” spacing_left_small=”” spacing_right_small=”” spacing_left=”0px” spacing_right=”0px” margin_top_medium=”” margin_bottom_medium=”” margin_top_small=”” margin_bottom_small=”” margin_top=”” margin_bottom=”0px” padding_top_medium=”” padding_right_medium=”” padding_bottom_medium=”” padding_left_medium=”” padding_top_small=”” padding_right_small=”” padding_bottom_small=”” padding_left_small=”” padding_top=”0px” padding_right=”0px” padding_bottom=”0px” padding_left=”0px” hover_type=”none” border_sizes_top=”0″ border_sizes_right=”0″ border_sizes_bottom=”0″ border_sizes_left=”0″ border_color=”” border_style=”solid” border_radius_top_left=”” border_radius_top_right=”” border_radius_bottom_right=”” border_radius_bottom_left=”” box_shadow=”no” box_shadow_vertical=”” box_shadow_horizontal=”” box_shadow_blur=”0″ box_shadow_spread=”0″ box_shadow_color=”” box_shadow_style=”” background_type=”single” gradient_start_color=”” gradient_end_color=”” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_color=”” background_image=”” background_position=”left top” background_repeat=”no-repeat” background_blend_mode=”none” animation_type=”” animation_direction=”left” animation_speed=”1.0″ animation_offset=”top-into-view” filter_type=”regular” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ last=”false” border_position=”all” first=”false” type=”1_3″][fusion_title title_type=”text” rotation_effect=”bounceIn” display_time=”1200″ highlight_effect=”circle” loop_animation=”off” highlight_width=”9″ highlight_top_margin=”0″ before_text=”” rotation_text=”” highlight_text=”” after_text=”” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”” id=”” content_align=”left” size=”3″ font_size=”” animated_font_size=”” fusion_font_family_title_font=”” fusion_font_subset_title_font=”” fusion_font_variant_title_font=”” line_height=”” letter_spacing=”” margin_top=”” margin_bottom=”0px” margin_top_mobile=”” margin_bottom_mobile=”” text_color=”” animated_text_color=”” highlight_color=”” style_type=”none” sep_color=”” animation_type=”” animation_direction=”left” animation_speed=”0.3″ animation_offset=”” margin_top_small=”” margin_bottom_small=””]

TERRY HERMISTON, Ph.D.
Director

[/fusion_title][fusion_separator style_type=”none” top_margin=”30px” bottom_margin=”30px” sep_color=”#969696″ border_size=”1px” width=”60%” alignment=”left” /][/fusion_builder_column][fusion_builder_column type=”1_3″ layout=”1_3″ align_self=”auto” content_layout=”column” align_content=”flex-start” content_wrap=”wrap” spacing=”no” center_content=”no” link=”” target=”_self” min_height=”” hide_on_mobile=”no” sticky_display=”normal,sticky” class=”” id=”” background_image_id=”” type_medium=”” type_small=”” order_medium=”0″ order_small=”0″ spacing_left_medium=”” spacing_right_medium=”” spacing_left_small=”” spacing_right_small=”” spacing_left=”0px” spacing_right=”” margin_top_medium=”” margin_bottom_medium=”” margin_top_small=”” margin_bottom_small=”” margin_top=”” margin_bottom=”0px” padding_top_medium=”” padding_right_medium=”” padding_bottom_medium=”” padding_left_medium=”” padding_top_small=”” padding_right_small=”” padding_bottom_small=”” padding_left_small=”” padding_top=”0px” padding_right=”0px” padding_bottom=”0px” padding_left=”0px” hover_type=”none” border_sizes_top=”0″ border_sizes_right=”0″ border_sizes_bottom=”0″ border_sizes_left=”0″ border_color=”” border_style=”solid” border_radius_top_left=”” border_radius_top_right=”” border_radius_bottom_right=”” border_radius_bottom_left=”” box_shadow=”no” box_shadow_vertical=”” box_shadow_horizontal=”” box_shadow_blur=”0″ box_shadow_spread=”0″ box_shadow_color=”” box_shadow_style=”” background_type=”single” gradient_start_color=”” gradient_end_color=”” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_color=”” background_image=”” background_position=”left top” background_repeat=”no-repeat” background_blend_mode=”none” animation_type=”” animation_direction=”left” animation_speed=”1.0″ animation_offset=”top-into-view” filter_type=”regular” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ last=”true” border_position=”all” first=”false” type=”1_3″][fusion_title title_type=”text” rotation_effect=”bounceIn” display_time=”1200″ highlight_effect=”circle” loop_animation=”off” highlight_width=”9″ highlight_top_margin=”0″ before_text=”” rotation_text=”” highlight_text=”” after_text=”” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”” id=”” content_align=”left” size=”3″ font_size=”” animated_font_size=”” fusion_font_family_title_font=”” fusion_font_subset_title_font=”” fusion_font_variant_title_font=”” line_height=”” letter_spacing=”” margin_top=”” margin_bottom=”0px” margin_top_mobile=”” margin_bottom_mobile=”” text_color=”” animated_text_color=”” highlight_color=”” style_type=”none” sep_color=”” animation_type=”” animation_direction=”left” animation_speed=”0.3″ animation_offset=”” margin_top_small=”” margin_bottom_small=””]

KURT ROTE, M.B.A.
Director

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PARTNERSHIPS

KaliVir Immunotherapeutics is committed to developing our pipeline through the establishment of strategic partnerships with leading immuno-oncology companies and academic groups. KaliVir is actively seeking development partnerships. For more information or inquiries on collaborations and partnerships, please send an inquiry by clicking below.

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STRATEGIC COLLABORATIONS

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KALIVIR is committed to providing the media with accurate and timely information. You can find our recent news releases below.

PRESS RELEASES

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DOWNLOAD / VIEW “2020 KaliVir – Astellas”
December 7. 2020 – KaliVir Immunotherapeutics and Astellas Enter Worldwide Exclusive Licensing Agreement for Development and Commercialization of VET2-L2 Novel Oncolytic Virus.

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DOWNLOAD / VIEW “TAXONOMICS”
How Stephen Thorne and Helena Chaye are blending their talents to create Breakthrough cancer fighting therapies.

PUBLICATIONS

[/fusion_title][fusion_separator style_type=”default” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”” id=”” sep_color=”#c6c6c6″ top_margin=”30px” bottom_margin=”60px” border_size=”1px” icon=”” icon_size=”” icon_circle=”” icon_circle_color=”” width=”40%” alignment=”center” /][fusion_separator style_type=”none” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”” id=”” sep_color=”#e0e0e0″ top_margin=”10px” bottom_margin=”10px” border_size=”1px” icon=”” icon_size=”” icon_circle=”” icon_circle_color=”” width=”40%” alignment=”center” /][/fusion_builder_column][fusion_builder_column type=”1_1″ layout=”1_1″ background_position=”left top” background_color=”” border_color=”” border_style=”solid” spacing=”yes” background_image=”” background_repeat=”no-repeat” padding_top=”” padding_right=”” padding_bottom=”” padding_left=”” margin_top=”0px” margin_bottom=”0px” class=”” id=”” animation_type=”” animation_speed=”0.3″ animation_direction=”left” hide_on_mobile=”no” center_content=”no” min_height=”none” last=”true” hover_type=”none” link=”” border_position=”all” align_self=”flex-start” border_sizes_top=”” border_sizes_bottom=”” border_sizes_left=”” border_sizes_right=”” first=”true” type=”1_1″][fusion_imageframe image_id=”584|full” max_width=”” sticky_max_width=”” style_type=”dropshadow” blur=”” stylecolor=”rgba(0,0,0,0.69)” hover_type=”none” bordersize=”” bordercolor=”” borderradius=”” align_medium=”none” align_small=”none” align=”center” margin_top=”” margin_right=”” margin_bottom=”” margin_left=”” lightbox=”no” gallery_id=”” lightbox_image=”” lightbox_image_id=”” alt=”” link=”Rivadeneira DB, DePeaux K, Wang Y, et al. Oncolytic Viruses Engineered to Enforce Leptin Expression Reprogram Tumor-Infiltrating T Cell Metabolism and Promote Tumor Clearance. Immunity. 2019;51(3):548-560.e4. doi:10.1016/j.immuni.2019.07.003″ linktarget=”_blank” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” class=”” id=”” animation_type=”slide” animation_direction=”left” animation_speed=”1.0″ animation_offset=”” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″]http://kalivir.macb.io/wp-content/uploads/2020/05/immunity.jpg[/fusion_imageframe][fusion_separator style_type=”none” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”” id=”” sep_color=”#e0e0e0″ top_margin=”10px” bottom_margin=”10px” border_size=”1px” icon=”” icon_size=”” icon_circle=”” icon_circle_color=”” width=”40%” alignment=”center” /][fusion_text columns=”” column_min_width=”” column_spacing=”” rule_style=”default” rule_size=”” rule_color=”” content_alignment_medium=”” content_alignment_small=”” content_alignment=”” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” class=”” id=”” font_size=”” fusion_font_family_text_font=”” fusion_font_variant_text_font=”” line_height=”” letter_spacing=”” text_color=”” animation_type=”” animation_direction=”left” animation_speed=”0.3″ animation_offset=””]

VIEW “IMMUNITY” PUBLICATION
Oncolytic Viruses Engineered to Enforce Leptin Expression Reprogram Tumor-Infiltrating T Cell Metabolism and Promote Tumor Clearance.

Rivadeneira DB, DePeaux K, Wang Y, et al. Oncolytic Viruses Engineered to Enforce Leptin Expression Reprogram Tumor-Infiltrating T Cell Metabolism and Promote Tumor Clearance. Immunity. 2019;51(3):548-560.e4. doi:10.1016/j.immuni.2019.07.003

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CAREERS

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We are actively hiring across multiple roles and disciplines and are working to build a world-class team that shares our commitment to help make a difference in patients’ lives through breakthrough science and medicines. If you are looking for your next career move and are interested in being part of a young, dynamic company where you could have a significant and long-term impact, please inquire about our open positions.

[/fusion_text][fusion_separator style_type=”none” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”” id=”” sep_color=”#e0e0e0″ top_margin=”20px” bottom_margin=”20px” border_size=”1px” icon=”” icon_size=”” icon_circle=”” icon_circle_color=”” width=”40%” alignment=”center” /][fusion_button link=”mailto:[email protected]?subject=Kalivir Employment Inquiry &body=1. Enter First and Last Name: %0D%0A%0D%0A 2. Enter Phone Number and email where we can reach you: %0D%0A%0D%0A 3. Enter your area of interest: %0D%0A%0D%0A 4. Enter best time of day to reach you:” text_transform=”” title=”” target=”_blank” link_attributes=”” alignment_medium=”” alignment_small=”” alignment=”center” modal=”” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” class=”” id=”” color=”default” button_gradient_top_color=”” button_gradient_bottom_color=”” button_gradient_top_color_hover=”” button_gradient_bottom_color_hover=”” accent_color=”” accent_hover_color=”” type=”” bevel_color=”” border_width=”” border_radius=”” border_color=”” border_hover_color=”” size=”xlarge” stretch=”no” margin_top=”” margin_right=”” margin_bottom=”” margin_left=”” icon=”” icon_position=”left” icon_divider=”no” animation_type=”” animation_direction=”left” animation_speed=”0.3″ animation_offset=””]JOIN OUR TEAM[/fusion_button][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container][fusion_builder_container hundred_percent=”yes” overflow=”visible” type=”legacy”][fusion_builder_row][fusion_builder_column type=”1_1″ layout=”1_1″ background_position=”left top” background_color=”” border_color=”” border_style=”solid” spacing=”yes” background_image=”” background_repeat=”no-repeat” padding_top=”” padding_right=”” padding_bottom=”” padding_left=”” margin_top=”0px” margin_bottom=”0px” class=”” id=”” animation_type=”” animation_speed=”0.3″ animation_direction=”left” hide_on_mobile=”no” center_content=”no” min_height=”none” last=”true” hover_type=”none” link=”” border_position=”all” align_self=”flex-start” border_sizes_top=”” border_sizes_bottom=”” border_sizes_left=”” border_sizes_right=”” first=”true” type=”1_1″][fusion_menu_anchor name=”contact” /][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container][fusion_builder_container hundred_percent=”no” equal_height_columns=”no” hide_on_mobile=”no” background_color=”#619e85″ background_position=”center bottom” background_repeat=”repeat-x” fade=”no” background_parallax=”none” enable_mobile=”no” parallax_speed=”0.3″ video_aspect_ratio=”16:9″ video_loop=”yes” video_mute=”yes” border_style=”solid” padding_top=”110px” padding_bottom=”115px” type=”legacy” border_sizes_top=”0px” border_sizes_bottom=”0px” border_sizes_left=”0px” border_sizes_right=”0px”][fusion_builder_row][fusion_builder_column type=”1_1″ layout=”1_1″ background_position=”left top” background_color=”” border_color=”” border_style=”solid” spacing=”yes” background_image=”” background_repeat=”no-repeat” padding_top=”” padding_right=”” padding_bottom=”” padding_left=”” margin_top=”0px” margin_bottom=”0px” class=”” id=”” animation_type=”” animation_speed=”0.3″ animation_direction=”left” hide_on_mobile=”no” center_content=”no” min_height=”none” last=”true” hover_type=”none” link=”” border_position=”all” align_self=”flex-start” border_sizes_top=”” border_sizes_bottom=”” border_sizes_left=”” border_sizes_right=”” first=”true” type=”1_1″][fusion_title title_type=”text” rotation_effect=”bounceIn” display_time=”1200″ highlight_effect=”circle” loop_animation=”off” highlight_width=”9″ highlight_top_margin=”0″ before_text=”” rotation_text=”” highlight_text=”” after_text=”” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” class=”” id=”” content_align=”center” size=”1″ font_size=”” animated_font_size=”” fusion_font_family_title_font=”” fusion_font_subset_title_font=”” fusion_font_variant_title_font=”” line_height=”” letter_spacing=”” margin_top=”0px” margin_bottom=”20px” margin_top_mobile=”” margin_bottom_mobile=”” text_color=”” animated_text_color=”” highlight_color=”” style_type=”none” sep_color=”” animation_type=”” animation_direction=”left” animation_speed=”0.3″ animation_offset=”” margin_top_small=”” margin_bottom_small=””]

CONTACT KALIVIR

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240 Alpha Drive
Pittsburgh, PA 15238
Phone: 1.412.435.6730
Email: [email protected]
Web: www.kalivir.com

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